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If a patient presents with carpal tunnel symptoms without a clear mechanical explanation, and particularly if they also describe other diffuse symptoms like fatigue, weight gain, or cold intolerance, hypothyroidism is worth flagging with the referring provider
In the Phase 2 obesity trial, the 12 mg weekly dose produced a mean weight reduction of about 24.2% at 48 weeks ( Jastreboff et al., NEJM 2023 ) the largest figure reported for any single agent in the incretin class at the time
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Adults: 1 capsule, 1 time per day
j , Body weight on day 14
For this reason, healthcare providers across North America, Europe, and Australia frequently prescribe it
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